Hyperuricemia - MeSH

Select item 680334611.

Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.

Year introduced: 2003

Select item 680079262.

Lesch-Nyhan Syndrome

An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)

Year introduced: 1973(1971)

Select item 675677603.

Hyperuricemic Nephropathy, Familial Juvenile 2 [Supplementary Concept]

Date introduced: August 24, 2012

Select item 675654894.

Hyperuricemia, Infantile, with Abnormal Behavior and Normal Hypoxanthine Guanine Phosphoribosyltransferase [Supplementary Concept]

Date introduced: November 5, 2012

Select item 675636935.

Glomerulocystic Kidney Disease with Hyperuricemia and Isosthenuria [Supplementary Concept]

Date introduced: November 5, 2012

Select item 675359956.

Deafness hyperuricemia neurologic ataxia [Supplementary Concept]