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1.

Interleukin-2

A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.

Year introduced: 1990(1978)

2.

Interleukin-2 Receptor beta Subunit

A receptor subunit that is a shared component of the INTERLEUKIN 2 RECEPTOR and the INTERLEUKIN-15 RECEPTOR. High affinity receptor complexes are formed with each of these receptors when their respective alpha subunits are combined with this beta subunit and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.

Year introduced: 2007(2001)

3.

Interleukin-2 Receptor alpha Subunit

A low affinity interleukin-2 receptor subunit that combines with the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN to form a high affinity receptor for INTERLEUKIN-2.

Year introduced: 2007(2001)

4.

Receptors, Interleukin-2

Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.

Year introduced: 1990(1989)

5.

Interleukin Receptor Common gamma Subunit

An interleukin receptor subunit that was originally discovered as a component of the INTERLEUKIN 2 RECEPTOR. It was subsequently found to be a component of several other receptors including the INTERLEUKIN 4 RECEPTOR, the INTERLEUKIN 7 RECEPTOR, the INTERLEUKIN-9 RECEPTOR, the INTERLEUKIN-15 RECEPTOR, and the INTERLEUKIN-21 RECEPTOR. Mutations in the gene for the interleukin receptor common gamma chain have been associated with X-LINKED COMBINED IMMUNODEFICIENCY DISEASES.

Year introduced: 2007(2000)

6.

IL2RG protein, human [Supplementary Concept]

RefSeq NM_000206

Date introduced: August 4, 2006

7.

interleukin 2 inhibitor [Supplementary Concept]

MW 11,000 t0 12,000; inhibits IL-2 but not IL-3-dependent proliferation

Date introduced: September 17, 1985

8.

interleukin-2 (22-58) [Supplementary Concept]

a synthetic fragment consisting of amino acids 22-58 contained 100% of the vasopermeability activity of IL-2 and was designated permeability-enhancing peptide (PEP)

Date introduced: June 2, 2003

9.

methionyl interleukin-2, alanine(125)- [Supplementary Concept]

recombinant human interleukin-2 analog

Date introduced: March 27, 1996

10.
11.

emt protein-tyrosine kinase [Supplementary Concept]

A non-receptor protein tyrosine kinase of the Tec family that participates in the intracellular signaling through antigen receptors such as the T-cell receptor, B-cell receptor, and Fc epsilon; amino acid sequence given in first source; isolated from murine mast cells; RefSeq NM_005546 (human), NM_010583 (mouse); do not confuse with TSK proteoglycan, mouse

Date introduced: May 17, 1993

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14.

interleukin-2 (59-72) [Supplementary Concept]

corresponds to 59-82 sequence of secreted human IL-2

Date introduced: October 3, 1985

15.

Interleukin 2 Receptor, Alpha, Deficiency of [Supplementary Concept]

mutation in IL2RA

Date introduced: November 5, 2012

16.

IL2 protein, human [Supplementary Concept]

RefSeq NM_000586

Date introduced: March 13, 2006

17.

Il2rb protein, rat [Supplementary Concept]

RefSeq NM_013195

Date introduced: August 4, 2006

18.

Il2rb protein, mouse [Supplementary Concept]

RefSeq NM_008368

Date introduced: August 4, 2006

19.

IL2RB protein, human [Supplementary Concept]

RefSeq NM_000878

Date introduced: August 4, 2006

20.

Il2ra protein, mouse [Supplementary Concept]

RefSeq NM_008367

Date introduced: August 4, 2006

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