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1.

Methimazole

A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.

Year introduced: 1973(1968)

2.

phenyl methimazole [Supplementary Concept]

inhibits TNF-alpha-induced VCAM-1 expression

Date introduced: September 10, 2004

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