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1.

Mitochondria

Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King and Stansfield, A Dictionary of Genetics, 4th ed)

Year introduced: MITOCHONDRIAL CONTRACTION was heading 1969-1996 (was see under MITOCHONDRIA 1975, was Prov 1969-1974)

2.

Mitochondria, Muscle

Mitochondria of skeletal and smooth muscle. It does not include myocardial mitochondria for which MITOCHONDRIA, HEART is available.

Year introduced: 1968

3.

Mitochondria, Liver

Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)

Year introduced: 1968

4.

Mitochondria, Heart

The mitochondria of the myocardium.

Year introduced: 1978

5.

Mitochondria Associated Membranes

Specialized areas of the endoplasmic reticulum in close physical contact with MITOCHONDRIA. These inter-organelle contact sites participate in the regulation of various processes such as MITOCHONDRIAL DYNAMICS; CALCIUM SIGNALING; ENERGY METABOLISM and INFLAMMATION.

Year introduced: 2024

6.

Mitochondrial Size

The quantity of volume or surface area of MITOCHONDRIA.

Year introduced: 2007

7.

Mitochondrial Diseases

Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.

Year introduced: 2002

8.

Mitochondrial Swelling

An increase in MITOCHONDRIAL VOLUME due to an influx of fluid; it occurs in hypotonic solutions due to osmotic pressure and in isotonic solutions as a result of altered permeability of the membranes of respiring mitochondria.

Year introduced: 1976(1969)

9.

MGARP protein, human [Supplementary Concept]

283 amino acid residues, 29.9 k Da; RefSeq NM_032623

Date introduced: August 6, 2004

10.

mitochondria proteolipid-like protein, human [Supplementary Concept]

a human carcinoma-associated tumor suppressor gene product; amino acid sequence given in first source; don't confuse with MPL protein, human

Date introduced: September 29, 1995

11.

Barth Syndrome

Rare congenital X-linked disorder of lipid metabolism. Barth syndrome is transmitted in an X-linked recessive pattern. The syndrome is characterized by muscular weakness, growth retardation, DILATED CARDIOMYOPATHY, variable NEUTROPENIA, 3-methylglutaconic aciduria (type II) and decreases in mitochondrial CARDIOLIPIN level. Other biochemical and morphological mitochondrial abnormalities also exist.

Year introduced: 2010

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17.

TEFM protein, human [Supplementary Concept]

RefSeq NM_024683

Date introduced: August 7, 2011

19.

MUL1 protein, human [Supplementary Concept]

RefSeq NM_024544

Date introduced: May 22, 2008

20.

SMCP protein, human [Supplementary Concept]

RefSeq NM_030663

Date introduced: August 6, 2004

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