Norepinephrine - MeSH

Select item 680096381.

Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic.

Year introduced: 1993 (1963)

Select item 680504842.

Norepinephrine Plasma Membrane Transport Proteins

Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of noradrenergic neurons. They remove NOREPINEPHRINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. The norepinephrine transporter regulates signal amplitude and duration at noradrenergic synapses and is the target of ADRENERGIC UPTAKE INHIBITORS.

Year introduced: 2006(1991)

Select item 680119413.

Receptors, Adrenergic

Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.

Year introduced: 1973(1971)

Select item 680106254.

Phenylethanolamine N-Methyltransferase

A methyltransferase that catalyzes the reaction of S-adenosyl-L-methionine and phenylethanolamine to yield S-adenosyl-L-homocysteine and N-methylphenylethanolamine. It can act on various phenylethanolamines and converts norepinephrine into epinephrine. (From Enzyme Nomenclature, 1992) EC 2.1.1.28.

Year introduced: 1974(1972)

Select item 674932275.

SLC6A2 protein, human [Supplementary Concept]

RefSeq NM_001043

Date introduced: July 29, 2005

Select item 670175746.

noradrenaline sulfate [Supplementary Concept]

Date introduced: January 1, 1978

Select item 670413737.

lidocaine, norepinephrine, vasopressin drug combination [Supplementary Concept]

local anesthetic combination used in dentistry containing above 3 cpds in sterile Ringer's solution

Date introduced: July 3, 1984

Select item 20098738.

Serotonin and Noradrenaline Reuptake Inhibitors

Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS.

Year introduced: 2016

Select item 675356009.

dopamine beta hydroxylase deficiency [Supplementary Concept]

A congenital syndrome caused by mutations in the dopamine beta-hydroxylase (DBH) gene. It is characterized by ORTHOSTATIC HYPOTENSION; frequent SYNCOPE especially following exercies, BLEPHAROPTOSIS; and delayed eye opening in affected neonates. Norepinephrine is greatly reduced in body fluids while dopamine is greatly increased. OMIM: 223360

Date introduced: August 25, 2010

Select item 6749322810.

Slc6a2 protein, mouse [Supplementary Concept]

RefSeq NM_009209

Date introduced: July 29, 2005

Select item 6749322611.

Slc6a2 protein, rat [Supplementary Concept]

RefSeq NM_031343

Date introduced: July 29, 2005

Select item 6708846212.

noradrenochrome [Supplementary Concept]

structure given in first source