Prolactin - MeSH

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Select item 680113881.

A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.

Select item 680566902.

Prolactin-Releasing Hormone

A hypothalamic hormone that is synthesized as a precursor protein which is cleaved into two peptides. In addition to stimulating PROLACTIN release the peptides bind to specific G-PROTEIN-COUPLED RECEPTORS found at locations within the BRAIN.

Year introduced: 2010, 1975-2006

Select item 680119813.

Receptors, Prolactin

Labile proteins on or in prolactin-sensitive cells that bind prolactin initiating the cells' physiological response to that hormone. Mammary casein synthesis is one of the responses. The receptors are also found in placenta, liver, testes, kidneys, ovaries, and other organs and bind and respond to certain other hormones and their analogs and antagonists. This receptor is related to the growth hormone receptor.

Year introduced: 1987

Select item 680113894.

Prolactin Release-Inhibiting Factors

A number of peptides with inhibitory activities on PROLACTIN release have been isolated from the HYPOTHALAMUS, the peripheral nervous system, and the gut. These include SOMATOSTATIN, and peptides derived from POMC and precursor for VASOPRESSIN-ASSOCIATED NEUROPHYSIN. Biogenic amine DOPAMINE is also a potent PIF.

Year introduced: 2007 (1975)

Select item 680151755.

Prolactinoma

A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.

Year introduced: 1989

Select item 680069666.

Hyperprolactinemia

Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)

Year introduced: 1986

Select item 680526827.

Lactotrophs

Anterior pituitary cells that produce PROLACTIN.

Year introduced: 2007

Select item 675343778.

PRLH protein, human [Supplementary Concept]

RefSeq NM_015893

Date introduced: August 13, 2009

Select item 670606789.

prolactin, polymeric [Supplementary Concept]

causes hyperprolactinemia; has substantially less biological activity than prolactin