MeSH

The common name for the genus Rattus.

Year introduced: 2006

Laboratory rats that have been produced from a genetically manipulated rat EGG or rat EMBRYO, MAMMALIAN. They contain genes from another species.

Year introduced: 2009

Mutant strains of rats that produce little or no hair. Several different homozygous recessive mutations can cause hairlessness in rats including rnu/rnu (Rowett nude), fz/fz (fuzzy), shn/shn (shorn), and nznu/nznu (New Zealand nude). Note that while NUDE RATS are often hairless, they are most characteristically athymic.

Year introduced: 2008

An inbred strain of Long-Evans rats that develops hyperglycemia, hyperinsulinemia, and mild obesity, mostly in males, that resembles non-insulin-dependent diabetes mellitus in humans. It was developed from outbred Long-Evans stock in 1983.

Year introduced: 1999

A cinnamon-colored strain of Long-Evans rats which carries a mutation causing fulminant hepatitis and jaundice, with an associated gross accumulation of copper in the liver. This strain is a model for Wilson's Disease (see HEPATOLENTICULAR DEGENERATION).

Year introduced: 1999

An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.

Year introduced: 1999

Inbred rats derived from Sprague-Dawley rats and used for the study of salt-dependent hypertension. Salt-sensitive and salt-resistant strains have been selectively bred to show the opposite genetically determined blood pressure responses to excess sodium chloride ingestion.

Year introduced: 1999

Any of several burrowing rodents of the families MURIDAE and Bathyergidae, found in eastern Europe, Africa, and Asia. They have short limbs, small eyes with permanently closed lids, and no tail. Three genera SPALAX (Muridae), Heterocephalus (Bathyergidae) and Cryptomys (Bathyergidae) are used frequently as experimental animals in biomedical research. (From Walker's Mammals of the World, 6th ed)

Year introduced: 1998

A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.

Year introduced: 1993

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

Year introduced: 1993

Two populations of Zucker rats have been cited in research--the "fatty" or obese and the lean. The "fatty" rat (Rattus norvegicus) appeared as a spontaneous mutant. The obese condition appears to be due to a single recessive gene.

Year introduced: 1991(1981)

A mutant strain of Rattus norvegicus without a thymus and with depressed or absent T-cell function. This strain of rats may have a small amount of hair at times, but then lose it.

Year introduced: 1991(1987)

Rats bearing mutant genes which are phenotypically expressed in the animals.

Year introduced: 1982

A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).

Year introduced: 1991(1985)

An inbred strain of rat that is used in BIOMEDICAL RESEARCH.

Year introduced: 1991(1972)

Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.

Year introduced: 1972

A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.

Year introduced: 1991(1985)

An inbred strain of rat that is used in BIOMEDICAL RESEARCH.

Year introduced: 1991(1972)

An inbred strain of rat that is used for general BIOMEDICAL RESEARCH purposes.

Year introduced: 1991(1972)

An inbred strain of rat that is used for cancer research, particularly the study of CARCINOGENESIS

Year introduced: 1991(1972)