MeSH

An antibiotic mixture of two components, A and B, obtained from Nocardia lurida (or the same substance produced by any other means). It is no longer used clinically because of its toxicity. It causes platelet agglutination and blood coagulation and is used to assay those functions in vitro.

Year introduced: RISTOMYCIN was heading 1965-1993 (Prov 1965-1972)

A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.

Year introduced: 1986(1976)

ristocetin A & B forms differentiated by paper chromatography; RN given refers to parent cpd; see also ristocetin: 1404-55-3

Date introduced: January 1, 1978

structure in first source

Date introduced: July 29, 2004

substantially greater antimicrobial activity against Gram-positive bacteria than the parent cpd; consists of the heptapeptide of ristocetin & the amino sugar ristosamin

Date introduced: February 17, 1983