Thyroxine - MeSH

Select item 680139741.

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.

Year introduced: 1965

Select item 680568252.

Thyroxine-Binding Globulin

A thyroid hormone transport protein found in serum. It binds about 75% of circulating THYROXINE and 70% of circulating TRIIODOTHYRONINE.

Year introduced: 2010(1992)

Select item 680139753.

Thyroxine-Binding Proteins

Blood proteins that bind to THYROID HORMONES such as THYROXINE and transport them throughout the circulatory system.

Year introduced: 1992

Select item 680074534.

Iodide Peroxidase

A hemeprotein that catalyzes the oxidation of the iodide radical to iodine with the subsequent iodination of many organic compounds, particularly proteins. EC 1.11.1.8.

Year introduced: 1986(1976)

Select item 670185395.

thyroxine, triiodothyronine drug combination [Supplementary Concept]

combination of sodium levothyroxine and sodium l-triiodothyronine in a ratio of 4 to 1 by weight; RN given refers to parent cpd

Date introduced: January 1, 1979

Select item 680119886.

Receptors, Thyroid Hormone

Specific high affinity binding proteins for THYROID HORMONES in target cells. They are usually found in the nucleus and regulate DNA transcription. These receptors are activated by hormones that leads to transcription, cell differentiation, and growth suppression. Thyroid hormone receptors are encoded by two genes (GENES, ERBA): erbA-alpha and erbA-beta for alpha and beta thyroid hormone receptors, respectively.

Year introduced: 1987

Select item 680039187.

Dextrothyroxine

The dextrorotary isomer of the synthetic THYROXINE.

Year introduced: 1965

Select item 670457368.

thyroxine sulfate [Supplementary Concept]

RN given for (L)-isomer

Date introduced: August 1, 1985

Select item 675801999.

Inherited Thyroxine-Binding Globulin Deficiency [Supplementary Concept]

Date introduced: October 24, 2013