BioAssays for PubChem Compound (Select 6251) - PubChem BioAssay - NCBI

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Select item 19635781.

p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:27 Active, 44 Activity ≤ 1 µM, 9667 Tested

AID:: 1963578

Select item 19635772.

p53 small molecule agonists, cell-based qHTS assay with human liver microsomes

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:43 Active, 55 Activity ≤ 1 µM, 9667 Tested

AID:: 1963577

Select item 19618453.

Antagonist activity at human TBXA2R in an in vitro cell-based assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Thromboxane A2 receptor

Assay data:34 Active, 15 Activity ≤ 1 µM, 906 Tested

AID:: 1961845

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618444.

Agonist activity at human TBXA2R in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Thromboxane A2 receptor

Assay data:13 Active, 8 Activity ≤ 1 µM, 927 Tested

AID:: 1961844

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618405.

Binding affinity towards human SLC6A4 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Sodium-dependent serotonin transporter

Assay data:99 Active, 36 Activity ≤ 1 µM, 927 Tested

AID:: 1961840

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618396.

Binding affinity towards human SLC6A3 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Sodium-dependent dopamine transporter

Assay data:128 Active, 38 Activity ≤ 1 µM, 927 Tested

AID:: 1961839

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618387.

Binding affinity towards human SLC6A2 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Sodium-dependent noradrenaline transporter

Assay data:137 Active, 27 Activity ≤ 1 µM, 927 Tested

AID:: 1961838

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618368.

Compound was evaluated for inhibition of rat Slc18a2 in an ex vivo assay measured by radioactivity method

Source:: ChEMBL

Protein Target:: Synaptic vesicular amine transporter

Assay data:39 Active, 1 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 82 Tested

AID:: 1961836

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618289.

Compound was evaluated for inhibition of human PTGS1 in an in vitro cell free assay measured by fluorescence method

Source:: ChEMBL

Protein Target:: Prostaglandin G/H synthase 1

Assay data:80 Active, 33 Activity ≤ 1 µM, 924 Tested

AID:: 1961828

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196182610.

Compound was evaluated for inhibition of human PTGS1 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: Prostaglandin G/H synthase 1

Assay data:96 Active, 35 Activity ≤ 1 µM, 927 Tested

AID:: 1961826

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196182011.

Binding affinity towards human PGR in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Progesterone receptor

Assay data:87 Active, 51 Activity ≤ 1 µM, 927 Tested

AID:: 1961820

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196181412.

Compound was evaluated for inhibition of human PDE4A in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A

Assay data:46 Active, 10 Activity ≤ 1 µM, 927 Tested

AID:: 1961814

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196181313.

Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Assay data:15 Active, 6 Activity ≤ 1 µM, 927 Tested

AID:: 1961813

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196181214.

Binding affinity towards human OPRM1 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Mu-type opioid receptor

Assay data:117 Active, 24 Activity ≤ 1 µM, 927 Tested

AID:: 1961812

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196178715.

Compound was evaluated for inhibition of human MAOA in an in vitro cell free assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Amine oxidase [flavin-containing] A

Assay data:13 Active, 5 Activity ≤ 1 µM, 927 Tested

AID:: 1961787

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196178616.

Compound was evaluated for inhibition of human KDR in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 2

Assay data:19 Active, 11 Activity ≤ 1 µM, 692 Tested

AID:: 1961786

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196177717.

Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2B

Assay data:3 Active, 5 Activity ≤ 1 µM, 927 Tested

AID:: 1961777

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196177218.

Binding affinity towards human HTR1A in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:141 Active, 68 Activity ≤ 1 µM, 927 Tested

AID:: 1961772

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196176919.

Binding affinity towards human HRH3 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Histamine H3 receptor

Assay data:23 Active, 11 Activity ≤ 1 µM, 927 Tested

AID:: 1961769

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196175720.

Binding affinity towards rat Gabra1 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Gamma-aminobutyric acid receptor subunit alpha-1

Assay data:6 Active, 1 Activity ≤ 1 µM, 532 Tested

AID:: 1961757

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Proteins (560)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (992)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (189)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (528)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (62)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (584)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (345)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (627)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (211)
BioAssays extracted from the literature
NIH MLP (506)
BioAssays deposited by the NIH Molecular Libraries Program
Other (435)
BioAssays deposited by other experimentalists

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