PMC full text:
Published online 2023 Mar 13. doi: 10.1038/s41584-023-00932-6
Table 2
Top sites identified as differentially methylated in primary Sjögren syndrome
| CpG site | Position (Chr:bp) | Gene | P value | Methylation status (hypermethylated (+) or hypomethylated (−)) | Tissue | Interferon induced?a | Refs. |
|---|---|---|---|---|---|---|---|
| cg07515989 | 1:43250763 | NA | 1.39 × 10−8 | + | Salivary glands | NA | 53 |
| cg03607951 | 1:79085586 | IFI44L | 9.9 × 10−67 | − | Blood and B cells | Yes | 52,53 |
| cg04268125 | 1:154579384 | ADAR | 1.83 × 10−11 | − | Blood | Yes | 52 |
| cg10549986 | 2:7018153 | RSAD2 | 1.4 × 10−17 | − | B cells | Yes | 53 |
| cg09858955 | 2:58135951 | VRK2 | 2.14 × 10−14 | − | Blood | Yes | 52 |
| cg22930808 | 3:122281881 | PARP9–DTX3L | 2.4 × 10−55 | − | Blood and B cells | Yes | 52,53 |
| cg06981309 | 3:146260954 | PLSCR1 | 4.1 × 10−51 | − | Blood and B cells | Yes | 52,53 |
| cg24678928 | 4:169240829 | DDX60 | 2.84 × 10−16 | − | Blood | Yes | 52 |
| cg17608381 | 6:29911550 | HLA-A | 3.4 × 10−15 | − | Blood | Yes | 53 |
| cg24399349 | 7:55517045 | NA | 2.38 × 10−8 | + | Salivary glands | NA | 53 |
| cg02680398 | 8:4629524 | CSMD1 | 1.22 × 10−8 | − | Salivary glands | No | 53 |
| cg01232121 | 8:58177661 | LOC286177 | 1.59 × 10−8 | − | Salivary glands | No | 53 |
| cg14864167 | 8:66751182 | PDE7A | 2.55 × 10−10 | − | Blood | Yes | 52 |
| cg06188083 | 10:91093005 | IFIT3 | 8.85 × 10−18 | − | Blood | Yes | 52 |
| cg05552874 | 10:91153143 | IFIT1 | 2.7 × 10−56 | − | Blood and B cells | Yes | 52,53 |
| cg06999856 | 10:135260170 | NA | 2.79 × 10−8 | + | Salivary glands | NA | 53 |
| cg23570810 | 11:315102 | IFITM1 | 6.1 × 10−38 | − | Blood and B cells | Yes | 52,53 |
| cg23198815 | 11:87184120 | NA | 3.73 × 10−8 | − | Salivary glands | NA | 53 |
| cg14943355 | 12:3980704 | PARP11 | 2.85 × 10−16 | − | Blood | Yes | 52 |
| cg04740359 | 12:5603542 | NTF3 | 1.39 × 10−9 | − | Salivary glands | Yes | 53 |
| cg20870559 | 12:113416518 | OAS2 | 1.02 × 10−9 | − | Salivary glands | Yes | 53 |
| cg12439472 | 13:43565399 | EPSTI1 | 2.32 × 10−17 | − | Blood | Yes | 52 |
| cg18329187 | 14:103989711 | CKB | 2.8 × 10−8 | + | Salivary glands | Yes | 53 |
| cg03425812 | 15:45005363 | B2M | 6.11 × 10−11 | − | Blood | Yes | 52 |
| cg07839457 | 16:57023022 | NLRC5 | 7.59 × 10−20 | − | Blood | Yes | 52 |
| cg25330422 | 17:40467382 | STAT3 | 3.2 × 10−13 | + | B cells | Yes | 53 |
| cg00871371 | 17:75371476 | SEPTIN9 | 3.15 × 10−8 | + | Salivary glands | No | 53 |
| cg16638092 | 17:78800774 | RPTOR | 1.72 × 10−8 | + | Salivary glands | No | 53 |
| cg05825244 | 20:2730488 | EBF4 | 2.4 × 10−11 | + | Blood | No | 53 |
| cg22862003 | 21:42797588 | MX1 | 7.9 × 10−63 | − | Blood and B cells | Yes | 52,53 |
| cg14293575 | 22:18635460 | USP18 | 9.7 × 10−14 | − | B cells | Yes | 53 |
bp, base pair; Chr, chromosome; CpG, cytosine guanine dinucleotide; NA, not available. aDefined as absolute fold change of 2.0 in the interferome database204.