Effect of Inhalation Profile on Delivery of Treprostinil Palmitil Inhalation Powder

Helena Gauani; Thomas Baker; Zhili Li; Vladimir S. Malinin; Walter R. Perkins; Eugene J. Sullivan; David Cipolla

doi:10.3390/pharmaceutics15030934

Figure 1

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Trapezoidal waveforms for various inhalation profiles at peak inspiratory flow rates of 60 LPM (1030 mL/s) and 30 LPM (510 mL/s) associated with data from Table S1. (A) The profiles show changes in acceleration rates: 50 ms (blue), 170 ms (orange), 500 ms (gray), 1000 ms (yellow), and 2000 ms (dark blue) ramp times to reach the 60 LPM peak flow rate corresponding to 20, 5.88, 2, 1, and 0.5 L/s² acceleration rates, respectively, for a 4 L inspired volume. (B) The profiles show changes in inspired volumes at the 50 ms ramp time corresponding to a 20 L/s² acceleration rate for the 1 L (red), 2 L (purple), and 4 L (blue) volume, and 2000 ms ramp time corresponding to a 0.5 L/s² acceleration rate at the 1 L (green), 2 L (dark red), and 4 L (dark blue) volume to reach the 60 LPM peak flow rate. (C) The profiles show changes in inspired volume at a 25 ms ramp time corresponding to a 20 L/s² acceleration rate at the 1 L (red), 2 L (purple), and 4 L (blue) volume and 1000 ms ramp time corresponding to a 0.5 L/s² acceleration rate at the 1 L (green), 2 L (dark red), and 4 L (dark blue) volume to reach the 30 LPM peak flow rate.