Table 2.
Linkage of seroreactivity between adeno-associated virus (AAV) serotypes in humans from 4 geographic areas.
| NAb titer, region, seroprevalent serotype | Seroreactivity linkage ratio | |||
|---|---|---|---|---|
| AAV1+/AAV1− | AAV2+/AAV2− | AAV7+/AAV7− | AAV8+/AAV8− | |
| >1:20 | ||||
| Africa | ||||
| AAV1 | … | 3.5 | 4.5 | 4.0 |
| AAV2 | 2.2 | … | 2.2 | 1.8 |
| AAV7 | 17.2 | 9.7 | … | 6.4 |
| AAV8 | 10.7 | 5.7 | 14.8 | … |
| Europe | ||||
| AAV1 | … | 26.3 | 29.4 | 11.5 |
| AAV2 | 7.0 | … | 6.8 | 5.0 |
| AAV7 | 184.5 | 126.2 | … | 17.3 |
| AAV8 | 51.8 | 35.3 | 57.9 | … |
| Australia | ||||
| AAV1 | … | 26.0 | 9.8 | 8.9 |
| AAV2 | 9.3 | … | 5.3 | 6.8 |
| AAV7 | 11.2 | 8.9 | … | 10.4 |
| AAV8 | 13.4 | 11.6 | 14.1 | … |
| United States | ||||
| AAV1 | … | 1.3 | 1.2 | 0.3 |
| AAV2 | 1.3 | … | 1.1 | 3.0 |
| AAV7 | 1.2 | 1.0 | … | 12.8 |
| AAV8 | 0.3 | 1.7 | 4.3 | … |
| >1:80 | ||||
| Africa | ||||
| AAV1 | … | 5.2 | 8.1 | 6.0 |
| AAV2 | 4.4 | … | 4.8 | 4.3 |
| AAV7 | 51.1 | 35.9 | … | 14.6 |
| AAV8 | 31.7 | 23.6 | 61.0 | … |
| Europe | ||||
| AAV1 | … | 25.1 | 13.2 | 9.4 |
| AAV2 | 16.5 | … | 9.7 | 7.8 |
| AAV7 | NA | NA | … | 32.1 |
| AAV8 | 56.6 | 50.2 | 95.8 | … |
| Australia | ||||
| AAV1 | … | 14.2 | 9.0 | 6.7 |
| AAV2 | 10.7 | … | 7.5 | 7.0 |
| AAV7 | NA | NA | … | 40.4 |
| AAV8 | 32.0 | 31.9 | 72.0 | … |
| United States | ||||
| AAV1 | … | 2.2 | NA | NA |
| AAV2 | 1.8 | … | 1.3 | 1.8 |
| AAV7 | NA | 1.0 | … | 47.5 |
| AAV8 | NA | 1.3 | 13.3 | … |
NOTE. See Materials and Methods and Results for details on calculating ratios. NA, not available (because the denominator in the ratio was zero).