Free Radical–Associated Gene Signature Predicts Survival in Sepsis Patients

Anlin Feng; Marissa D. Pokharel; Ying Liang; Wenli Ma; Saurabh Aggarwal; Stephen M. Black; Ting Wang

doi:10.3390/ijms25084574

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Immune Profiling of PBMCs in sepsis low and high-risk groups. KEGG analysis for (A) up-regulated or (B) down-regulated DEGs in low sepsis survival scores (C) Gene set variation analysis heatmap reveals the variations of pathways between high and low sepsis survival scores. (D) Using CIBERSORT, immune cell proportions in PBMCs were estimated. (E) In patients with high sepsis survival scores, neutrophils are predicted to be increased, while CD8+ T and NK cells are predicted to be decreased. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. (F,G) T and NK cell pathways were significantly decreased in patients with high sepsis survival scores. NES: normalized enrichment score.