Figure 6

Local LTP in the ACC does not require NO. (a) Microphotograph and schematic diagram showing one example of ACC fEPSP recorded by using the MED64 system. A cortex slice containing the ACC was placed on a probe with 64 electrodes (MED-P515A, 8 × 8 array). One channel of the probe was selected as the stimulation site. The evoked field potentials in all the other channels were recorded 30 min before and 1 h after the TBS. (b) Two mapped figures show the evoked field potentials in the ACC with or without L-NAME perfusion. Field potentials were recorded from the other 63 channels 0.5 h before (black) and 3 h (red) after TBS was delivered to one channel marked ‘s’ with red circles. The fEPSP slope of 4 channels (differentiated by four different colors) with LTP (c) and 2 channels without potentiation (d) from 1 slice in L-NAME is shown, respectively. The average slope of the total 6 channels is shown in (e). The fEPSP slope of 6 channels with LTP (f) and 2 channels without potentiation (g) from 1 slice in the control condition is shown, respectively. The average slope of the total 8 channels is shown in (h). (i) Time course of the averaged fEPSP slope of all recorded channels in L-NAME and control ACSF (7 slices/5 mice in the L-NAME group and 3 slices/3 mice in the control group).