Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors

Michael L. Whitfield; Gavin Sherlock; Alok J. Saldanha; John I. Murray; Catherine A. Ball; Karen E. Alexander; John C. Matese; Charles M. Perou; Myra M. Hurt; Patrick O. Brown; David Botstein

doi:10.1091/mbc.02-02-0030.

Figure 8

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M/G1 clusters. Three clusters of M/G1 genes from Figure Figure3B3B are shown in more detail. Each contains genes involved in cell adhesion, chromosome metabolism and RAS signal transduction and is annotated as described in Figure Figure6.6. Cluster A, (NODE568X) contains 104 clones (33 ESTs and hypothetical proteins); 37% show peak expression in G2/M and 63% show peak expression in M/G1. Cluster B, (NODE688X) is comprised of 12 clones (three ESTs), including CDK7, the cdk of the cdk-activating complex (CAK); 92% show peak expression in M/G1. Cluster C, (NODE988X) which peaks in late M/G1, contains 25 clones (eight ESTs and hypothetical proteins); 96% peak in M/G1. The full clusters with all gene names, phase assignments and annotations can be viewed in Supplemental Figure 14.