Fig 1.

Body weight responses to angiogenesis inhibitors. We treated 8-week-old ob/ob mice with various doses of TNP-470 (A) or angiostatin (B) for 21 days (n = 4 per group). (C) Responses of ob/ob mice treated with various angiogenesis inhibitors (hatched bars) for 7 d were compared with those of the corresponding vehicles (solid bars) and leptin (n = 3 per group). (D) Twelve-week-old mice from various obesity models were treated with vehicle (solid bars) or TNP-470 (hatched bars) for 7 days (n = 3 per group). These included agouti mice C57BL/6J-A^y (A^y), fat mice C57BLKS-Cpe^fat/J (Cpe^fat), ob/ob mice C57BL/6J-Lep^ob, and wild-type C57BL/6J mice fed a high-fat diet consisting of 40% fat by calorie (n = 3 per group).