Differential Regulation of Tumor Angiogenesis by Distinct ErbB Homo- and Heterodimers

Lily Yen; Naciba Benlimame; Zeng-Rong Nie; Dingzhang Xiao; Taiqi Wang; Ala-Eddin Al Moustafa; Hiroyasu Esumi; Julie Milanini; Nancy E. Hynes; Gilles Pages; Moulay A. Alaoui-Jamali

doi:10.1091/mbc.E02-02-0084

Figure 5

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Overexpression of ErbB-2 in human MCF7 breast cancer cells. Serum-starved MCF7-neo22, -HER218, -AP2, and -ErbB-2 cells were stimulated with 50 ng/ml EGF or 100 ng/ml HRG for 10 min. ErbB-2 was immunoprecipitated, and tyrosine phosphorylation of the receptor was determined with anti-phosphotyrosine antibody. The blot was then stripped and probed with anti-ErbB-2 antibody.