Learn more: PMC Disclaimer | PMC Copyright Notice
The excretion of zopiclone into breast milk.
Abstract
1. The excretion of zopiclone into breast milk was studied in 12 lactating women in the early postpartum period following the oral administration of a single zopiclone tablet (7.5 mg). 2. The milk/plasma AUC ratio of zopiclone was 0.51 +/- 0.09 (mean +/- s.d.). Individual mean milk/plasma concentration ratios of zopiclone showed significant interindividual variation (range 0.41-0.70). 3. A comparison of pharmacokinetic parameters in the postpartum women with those reported previously in non-pregnant women, showed significantly higher Cmax values in the lactating mothers; tmax occurred later in milk than in maternal plasma. 4. Assuming a daily milk intake of 0.15 l kg-1 and 100% absorption the average infant dose of zopiclone in milk would be 1.4% of the weight adjusted dose ingested by the mother.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (539K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Channer KS, Dent M, Roberts CJ. The effect of posture at the time of administration on the central depressant effects of the new hypnotic zopiclone. Br J Clin Pharmacol. 1984 Dec;18(6):879–886. [PMC free article] [PubMed] [Google Scholar]
- Cummings AJ. A survey of pharmacokinetic data from pregnant women. Clin Pharmacokinet. 1983 Jul-Aug;8(4):344–354. [PubMed] [Google Scholar]
- Gaillot J, Heusse D, Hougton GW, Marc Aurele J, Dreyfus JF. Pharmacokinetics and metabolism of zopiclone. Pharmacology. 1983;27 (Suppl 2):76–91. [PubMed] [Google Scholar]
- Goa KL, Heel RC. Zopiclone. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy as an hypnotic. Drugs. 1986 Jul;32(1):48–65. [PubMed] [Google Scholar]
- Houghton GW, Dennis MJ, Templeton R, Martin BK. A repeated dose pharmacokinetic study of a new hypnotic agent, zopiclone (Imovane). Int J Clin Pharmacol Ther Toxicol. 1985 Feb;23(2):97–100. [PubMed] [Google Scholar]
- Matheson I. Medikamentrutiner ved norske barselavdelinger. Tidsskr Nor Laegeforen. 1985 Nov 20;105(32):2281–2284. [PubMed] [Google Scholar]
- Matheson I. Medikamenter til mor og barn i barselavdeling. En kartlegging ved fem norske universitetssykehus. Tidsskr Nor Laegeforen. 1989 Aug 10;109(22):2118–2122. [PubMed] [Google Scholar]
- Notarianni LJ. Plasma protein binding of drugs in pregnancy and in neonates. Clin Pharmacokinet. 1990 Jan;18(1):20–36. [PubMed] [Google Scholar]
- Passmore CM, McElnay JC, D'Arcy PF. Drugs taken by mothers in the puerperium: inpatient survey in Northern Ireland. Br Med J (Clin Res Ed) 1984 Dec 8;289(6458):1593–1596. [PMC free article] [PubMed] [Google Scholar]
- Wickstrøm E, Giercksky KE. Comparative study of zopiclone, a novel hypnotic, and three benzodiazepines. Eur J Clin Pharmacol. 1980 Feb;17(2):93–99. [PubMed] [Google Scholar]
- Wilson JT, Brown RD, Hinson JL, Dailey JW. Pharmacokinetic pitfalls in the estimation of the breast milk/plasma ratio for drugs. Annu Rev Pharmacol Toxicol. 1985;25:667–689. [PubMed] [Google Scholar]