Properties and Dissemination of H5N1 Viruses Isolated during an Influenza Outbreak in Migratory Waterfowl in Western China

Hualan Chen; Yanbing Li; Zejun Li; Jianzhong Shi; Kyoko Shinya; Guohua Deng; Qiaoling Qi; Guobin Tian; Shufang Fan; Haidan Zhao; Yingxiang Sun; Yoshihiro Kawaoka

doi:10.1128/JVI.00110-06

FIG. 3.

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Histopathologic analysis of a moribund bar-headed goose from the H5N1 virus outbreak at Qinghai Lake. (a) Brain showing scattered nonsuppurative inflammatory foci characterized by perivascular cuffing of mononuclear cells, microgliosis, degeneration of nerve cells, and edema (HE stain). (b) Brain with numerous nerve and glial cells positive for viral antigen (brown pigments) by immunohistological staining with an anti-H5 polyclonal antibody. (c) Pancreas showing scattered coagulative necrotic foci in parenchyma with nonsuppurative inflammation (HE stain). (d) Heart showing small nonsuppurative inflammatory foci with degenerating cardiomyocytes (HE stain).