TABLE 3.
Titers of viruses isolated from rhesus macaques infected with H5N1 avian influenza virusesa
| Virus | Days postinfection | Virus titers in organs of nonhuman primates (log10 EID50/ml)a
| ||||||
|---|---|---|---|---|---|---|---|---|
| Nasal swab | Lung lavage | Tonsil | Lung | Spleen | Liver | Heart | ||
| BHGs/QH/1/05 | 4 | < | < | < | < | < | < | < |
| 7 | < | < | < | < | < | < | < | |
| GC/QH/3/05 | 4 | < | < | < | < | < | < | < |
| 7 | < | < | < | < | < | < | < | |
| DK/GX/35/01 | 4 | 2.5 | 3.5 | ND | 1.5 | 4.5 | + | 1.3 |
| 7 | < | 3.8 | ND | 1.5 | < | < | < | |
aThree-year-old, colony-bred, female rhesus macaques (Macaca mulatta) were infected intranasally with 107 EID50 of the viruses in 2 ml of phosphate-buffered saline. One animal from each group was euthanized on days 4 and 7 postinfection by exsanguination under ketamine anesthesia. Nasal swabs, bronchoalveolar lavage specimens, and organs from the euthanized animals were collected for virus titration. <, virus was not detected; ND, not determined; +, virus was detected only in the original samples.