Muscle oxidative stress after exhaustive physical exercise in ratsA, allopurinol prevents oxidation of glutathione (GSSG) in exhaustive exercise. Values are means ±s.d.; Rest, n = 5; Exercised, n = 4; Exercised treated with allopurinol, n = 4. *P < 0.05 versus Rest. B, reduced glutathione (GSH) muscle levels in exhaustive exercise. Values are means ±s.d.; Rest, n = 5; Exercised, n = 4; Exercised treated with allopurinol, n = 4.