Failure to prolyl hydroxylate hypoxia-inducible factor α phenocopies VHL inactivation in vivo

William Y Kim; Michal Safran; Marshall R M Buckley; Benjamin L Ebert; Jonathan Glickman; Marcus Bosenberg; Meredith Regan; William G Kaelin, Jr

doi:10.1038/sj.emboj.7601300

Figure 3

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Gross phenotypes of K14-Cre;HIF2dPA mice and K14-Cre;VHL^f/f mice. (A) Immunoblot analysis of skin biopsy homogenates prepared from mice with the indicated genotypes. (B) Photographs of representative K14-Cre;HIF2dPA and K14-Cre;VHL^f/f mice alongside age and sex-matched K14-Cre control. (C) Growth curves of mean body weight of K14-Cre;HIF2dPA, K14-Cre;VHL^f/f mice, and K14-Cre mice.