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Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke
Abstract
Diffusion tensor imaging (DTI) fully characterises water
molecule mobility in vivo, allowing an exploration of fibre tract integrity and orientation in the human brain.
Using DTI this study demonstrates reduced fibre coherence
(anisotropy) associated with cerebral infarction and in the
corticospinal tract remote from the lesion, in five patients 2 to 6 months after ischaemic stroke. The study highlights the potential of
DTI to detect and monitor the structural degeneration of fibre
pathways, which may provide a better understanding of the pattern of
clinical evolution after stroke.
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