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Br J Pharmacol. 1974 Mar; 50(3): 375–381.
doi: 10.1111/j.1476-5381.1974.tb09612.x
PMCID: PMC1776676
PMID: 4853047

Lowering of kininogen in rat blood by adrenaline and its inhibition by sympatholytic agents, heparin and aspirin

A. Castania and A.M. Rothschild
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Abstract

1 (-)-Adrenaline lowered the kininogen content and transitorily elevated the fibrinolytic activity of plasma following intravenous injection into the rat. Its effect on kininogen increased when administered by intravenous infusion.

2 Although less effective, (-)-noradrenaline had a similar action to adrenaline; (±)-isoprenaline was inactive and failed to inhibit the effect of adrenaline.

3 The effect of adrenaline on kininogen could be reproduced in vitro by incubation of whole blood, but not cell-free plasma, with the catecholamine for 5 min at 37° C.

4 Propranolol or phenoxybenzamine, as well as heparin or acetylsalicylic acid (aspirin), blocked the reduction of rat blood kininogen by adrenaline in vivo and in vitro.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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