TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA

Kristina M. Johnson; Jin Wang; Andrea Smallwood; Charina Arayata; Michael Carey

doi:10.1101/gad.995702

Figure 7

An external file that holds a picture, illustration, etc.
Object name is 51070-4f7_F1TT.jpg

Model of cooperative recruitment of coactivators to DNA templates. Our hypothesis is that reciprocal, cooperative interactions between activator (or series of activators), TFIID, hMed, and template DNA determine the stability of a higher-order nucleoprotein complex. The presence of some form of this higher-order assembly is required for all activated transcription. A key feature of this model is direct communication between the hMed and TFIID.