Figure 7
Model of cooperative recruitment of coactivators to DNA templates. Our hypothesis is that reciprocal, cooperative interactions between activator (or series of activators), TFIID, hMed, and template DNA determine the stability of a higher-order nucleoprotein complex. The presence of some form of this higher-order assembly is required for all activated transcription. A key feature of this model is direct communication between the hMed and TFIID.