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Am J Hum Genet. 1964 Sep; 16(3): 311–335.
PMCID: PMC1932478
PMID: 14207548

The Coexistence of the Genes for Hemoglobin E and α Thalassemia in Thais, with Resultant Suppression of Hemoglobin E Synthesis

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  • AGER JA, LEHMANN H. Observations on some fast haemoglobins: K, J, N, and Bart's. Br Med J. 1958 Apr 19;1(5076):929–931. [PMC free article] [PubMed] [Google Scholar]
  • AKSOY M, LEHMANN H. Sickle-cell-thalassaemia disease in South Turkey. Br Med J. 1957 Mar 30;1(5021):734–738. [PMC free article] [PubMed] [Google Scholar]
  • ATWATER J, SCHWARTZ IR, ERSLEV AJ, MONTGOMERY TL, TOCANTINS LM. Sickling of erythrocytes in a patient with thalassemia-hemoglobin-I disease. N Engl J Med. 1960 Dec 15;263:1215–1223. [PubMed] [Google Scholar]
  • BINGLE JP, HUEHNS ER, PRANKERD TA. Haemoglobin-H disease. Br Med J. 1958 Dec 6;2(5109):1389–1390. [PMC free article] [PubMed] [Google Scholar]
  • BOYER SH, RUCKNAGEL DL, WEATHERALL DJ, WATSON-WILLIAMS EJ. FURTHER EVIDENCE OF LINKAGE BETWEEN THE BETA AND DELTA LOCI GOVERNING HUMAN HEMOGLOBIN AND THE POPULATION DYNAMICS OF LINKED GENES. Am J Hum Genet. 1963 Dec;15:438–448. [PMC free article] [PubMed] [Google Scholar]
  • CHERNOFF AI, LIU JC. The amino acid composition of hemoglobin. II. Analytical technics. Blood. 1961 Jan;17:54–70. [PubMed] [Google Scholar]
  • CHERNOFF AI, MINNICH V, NANAKORN S, TUCHINDA S, KASHEMSANT C, BANGKOK, THAILAND, CHERNOFF RR. Studies on hemoglobin E. I. The clinical, hematologic, and genetic characteristics of the hemoglobin E syndromes. J Lab Clin Med. 1956 Mar;47(3):455–489. [PubMed] [Google Scholar]
  • CHOREMIS C, ZANNOS-MARIOLEA L, AGER JA, LEHMANN H. Persistence of haemoglobin "Bart's" beyond infancy in a child with thalassaemia. Br Med J. 1959 Sep 5;2(5148):348–349. [PMC free article] [PubMed] [Google Scholar]
  • COHEN F, ZUELZER WW, NEEL JV, ROBINSON AR. Multiple inherited erythrocyte abnormalities in an American Negro family: hereditary spherocytosis, sickling and thalassemia. Blood. 1959 Jul;14(7):816–827. [PubMed] [Google Scholar]
  • DITTMAN WA, HAUT A, WINTROBE MM, CARTWRIGHT GE. Hemoglobin H associated with an uncommon variant of thalassemia trait. Blood. 1960 Jul;16:975–983. [PubMed] [Google Scholar]
  • DORMANDY KM, LOCK SP, LEHMANN H. Haemoglobin Q-alpha-thalassaemia. Br Med J. 1961 Jun 3;1(5239):1582–1585. [PMC free article] [PubMed] [Google Scholar]
  • FESSAS P, PAPASPYROU A. New fast hemoglobin associated with thalassemia. Science. 1957 Nov 29;126(3283):1119–1119. [PubMed] [Google Scholar]
  • GAMMACK DB, HUEHNS ER, LEHMANN H, SHOOTER EM. The abnormal polypeptide chains in a number of haemoglobin variants. Acta Genet Stat Med. 1961;11:1–16. [PubMed] [Google Scholar]
  • GERALD PS, DIAMOND LK. The diagnosis of thalassemia trait by starch block electrophoresis of the hemoglobin. Blood. 1958 Jan;13(1):61–69. [PubMed] [Google Scholar]
  • GOUTTAS A, FESSAS P, TSEVRENIS H, XEFTERI E. Description d'une nouvelle variété d'anémie hémolytique congénitale; etude hématologique, électrophorétique et génétique. Sang. 1955;26(9):911–919. [PubMed] [Google Scholar]
  • HEDENBERG F, MULLER-EBERHARD U, SJOLIN S, WRANNE L. Haemoglobin H and inclusion-body anaemia in a Swedish family. Acta Paediatr. 1958 Nov;47(6):652–665. [PubMed] [Google Scholar]
  • HUISMAN TH, MARTIS EA, DOZY A. Chromatography of hemoglobin types on carboxymethylcellulose. J Lab Clin Med. 1958 Aug;52(2):312–327. [PubMed] [Google Scholar]
  • HUNT JA, INGRAM VM. Abnormal human haemoglobins. IV. The chemical difference between normal human haemoglobin and haemoglobin C. Biochim Biophys Acta. 1960 Aug 26;42:409–421. [PubMed] [Google Scholar]
  • HUNT JA, LEHMANN H. Haemoglobin "Bart's': a foetal haemoglobin without alpha-chains. Nature. 1959 Sep 19;184:872–873. [PubMed] [Google Scholar]
  • INGRAM VM. Abnormal human haemoglobins. I. The comparison of normal human and sickle-cell haemoglobins by fingerprinting. Biochim Biophys Acta. 1958 Jun;28(3):539–545. [PubMed] [Google Scholar]
  • INGRAM VM. Biochemical genetics at the molecular level. Am J Med. 1963 May;34:674–679. [PubMed] [Google Scholar]
  • INGRAM VM, STRETTON AO. Genetic basis of the thalassaemia diseases. Nature. 1959 Dec 19;184:1903–1909. [PubMed] [Google Scholar]
  • ITANO HA, BERGREN WR, STURGEON P. The abnormal human hemoglobins. Medicine (Baltimore) 1956 May;35(2):121–159. [PubMed] [Google Scholar]
  • KATZ AM, DREYER WJ, ANFINSEN CB. Peptide separation by two-dimensional chromatography and electrophoresis. J Biol Chem. 1959 Nov;234:2897–2900. [PubMed] [Google Scholar]
  • KOLER RD, RIGAS DA. Genetics of haemoglobin H. Ann Hum Genet. 1961 May;25:95–100. [PubMed] [Google Scholar]
  • KUNKEL HG, CEPPELLINI R, MULLER-EBERHARD U, WOLF J. Observations on the minor basic hemoglobin component in the blood of normal individuals and patients with thalassemia. J Clin Invest. 1957 Nov;36(11):1615–1625. [PMC free article] [PubMed] [Google Scholar]
  • KUNKEL HG, WALLENIUS G. New hemoglobin in normal adult blood. Science. 1955 Aug 12;122(3163):288–288. [PubMed] [Google Scholar]
  • ENG LL, TJIANG TG, KENG KL. Splenectomy in a case of chronic haemolytic anaemia associated with haemoglobin H. J Trop Med Hyg. 1961 Jun;64:136–139. [PubMed] [Google Scholar]
  • LIE-INJO LE. Alpha-chain thalassemia and hydrops fetalis in Malaya: report of five cases. Blood. 1962 Nov;20:581–590. [PubMed] [Google Scholar]
  • ENG LIL, HIN PS, KENG KL, ENDENBURG PM. Chronic hypochromic microcytic anaemia associated with haemoglobin H. Acta Haematol. 1957 Aug;18(2):156–167. [PubMed] [Google Scholar]
  • MINNICH V, CORDONNIER JK, WILLIAMS WJ, MOORE CV. Alpha, beta and gamma hemoglobin polypeptide chains during the neonatal period with description of a fetal form of hemoglobin Da-St. Louis. Blood. 1962 Feb;19:137–167. [PubMed] [Google Scholar]
  • MINNICH V, NA-NAKORN S, CHONG-CHAREONSUK S, KOCHASENI S. Mediterranean anemia; a study of thirty-two cases in Thailand. Blood. 1954 Jan;9(1):1–23. [PubMed] [Google Scholar]
  • MOTULSKY AG. Genetic and haematological significance of haemoglobin H. Nature. 1956 Nov 10;178(4541):1055–1056. [PubMed] [Google Scholar]
  • MOTULSKY AG. Controller genes in synthesis of human haemoglobin. Nature. 1962 May 12;194:607–609. [PubMed] [Google Scholar]
  • NA-NAKORN S, BANGKOK, THAILAND, MINNICH V, CHERNOFF AI. Studies on hemoglobin E. II. The incidence of hemoglobin E in Thailand. J Lab Clin Med. 1956 Mar;47(3):490–498. [PubMed] [Google Scholar]
  • Nance WE. Genetic Control of Hemoglobin Synthesis. Science. 1963 Jul 12;141(3576):123–130. [PubMed] [Google Scholar]
  • NEEL JV. The hemoglobin genes: a remarkable example of the clustering of related genetic functions on a single mammalian chromosome. Blood. 1961 Dec;18:769–777. [PubMed] [Google Scholar]
  • PEARSON HA, McFARLAND W. Erythrokinetics in thalassemia. II. Studies in Lepore trait and hemoglobin H disease. J Lab Clin Med. 1962 Jan;59:147–157. [PubMed] [Google Scholar]
  • QUATTRIN N, VENTRUTO V, DINI E, ALOIA L. [On the association of Bart's hemoglobin and microcythemia. First Italian case]. Minerva Med. 1961 Sep 19;52:3189–3197. [PubMed] [Google Scholar]
  • RAMOT B, SHEBA C, FISHER S, AGER JA, LEHMANN H. Haemoglobin H disease with persistent haemoglobin "Bart's" in an Oriental Jewess and her daughter: a dual alpha-chain deficiency of human haemoglobin. Br Med J. 1959 Dec 5;2(5161):1228–1230. [PMC free article] [PubMed] [Google Scholar]
  • RIGAS DA, KOLER RD, OSGOOD EE. Hemoglobin H; clinical, laboratory, and genetic studies of a family with a previously undescribed hemoglobin. J Lab Clin Med. 1956 Jan;47(1):51–64. [PubMed] [Google Scholar]
  • SINGER K, CHERNOFF AI, SINGER L. Studies on abnormal hemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali denaturation. Blood. 1951 May;6(5):413–428. [PubMed] [Google Scholar]
  • Singer SJ, Itano HA. ON THE ASYMMETRICAL DISSOCIATION OF HUMAN HEMOGLOBIN. Proc Natl Acad Sci U S A. 1959 Feb;45(2):174–184. [PMC free article] [PubMed] [Google Scholar]
  • SMITH EW, CONLEY CL. Filter paper electrophoresis of human hemoglobins with special reference to the incidence and clinical significance of hemoglobin C. Bull Johns Hopkins Hosp. 1953 Aug;93(2):94–106. [PubMed] [Google Scholar]
  • TUCHINDA S, VAREENIL C, BHANCHIT P, MINNICH V. Fast hemoglobin component found in umbilical-cord blood of Thai babies. Pediatrics. 1959 Jul;24(1):43–49. [PubMed] [Google Scholar]
  • VELLA F, WELLS RH, AGER JA, LEHMANN H. A haemoglobinopathy involving haemoglobin H and a new (Q) haemoglobin. Br Med J. 1958 Mar 29;1(5073):752–755. [PMC free article] [PubMed] [Google Scholar]
  • WOLFF JA, MICHAELS RH, VON HOFF FH. Hemoglobin H-thalassemia disease. Blood. 1958 May;13(5):492–501. [PubMed] [Google Scholar]
  • ZUELZER WW, KAPLAN E. Thalassemia-hemoglobin C disease; a new syndrome presumably due to the combination of the genes for thalassemia and hemoglobin C. Blood. 1954 Nov;9(11):1047–1054. [PubMed] [Google Scholar]
  • NEEL JV, ROBINSON AR, ZUELZER WW. Abnormal hemoglobins. Prog Hematol. 1956;1:91–137. [PubMed] [Google Scholar]

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