Differences in the relative potency of SR 141716A and AM 251 as antagonists of various in vivo effects of cannabinoid agonists in C57BL/6J mice

Lance R. McMahon; Wouter Koek

doi:10.1016/j.ejphar.2007.04.054

Table 2

ED₅₀ values in mg/kg for agonist-induced catalepsy, ID₅₀ values in mg/kg for antagonism of agonist-induced catalepsy, and corresponding potency ratios and 95% confidence limits (95% CL). Potency ratios are expressed as a ratio of the least potent divided by the most potent.

Catalepsy	*ED₅₀ (95% CL)*	*Potency Ratio (95% CL)*
Δ⁹-THC	7.9 (5.3−12)
WIN 55212−2	4.5 (2.8−7.1)	1.8 (1.0−3.1)
Δ⁹-THC antagonism	*ID₅₀ (95% CL)*
AM 251	1.5 (0.80−2.8)
SR 141716A	0.25 (0.13−0.47)	6.1 (2.5−15)^a
WIN 55212−2 antagonism
AM 251	4.8 (0.88−27)
SR 141716A	0.90 (0.44−1.8)	5.4 (1.8−16)^a

^asignificant difference in ID₅₀