Systemic inflammation and lung function in young adults

Robert J Hancox; Richie Poulton; Justina M Greene; Susan Filsell; Christene R McLachlan; Finn Rasmussen; D Robin Taylor; Michael J A Williams; Avis Williamson; Malcolm R Sears

doi:10.1136/thx.2006.076877

Table 4 Longitudinal analyses of the association between decline in FEV₁ from age 26 to 32 and CRP at age 26 and 32

Outcome	Predictor	Covariates	n	Coefficient (95% CI)	p Value
Fall in FEV₁ (ml)	Age 26 log‐CRP	Sex, height	766	−3.30 (−25.1 to 18.5)	0.77
Fall in FEV₁ (ml)	Age 26 log‐CRP	Sex, height, smoking, asthma	765	−2.55 (−24.4 to 19.3)	0.82
Age 32 log‐CRP	Fall in FEV₁ (litres)	Sex, height	788	0.48 (0.25 to 0.71)	<0.001
Age 32 log‐CRP	Fall in FEV₁ (litres)	Sex, height, smoking, asthma, age 26 CRP	739	0.49 (0.26 to 0.71)	<0.001

CRP, C‐reactive protein; FEV₁, forced expiratory volume in one second.

CRP values were log transformed for analysis and are expressed as standard deviation scores. Analyses exclude women who were pregnant at either age. *Analyses adjusted for history of smoking between age 26 and 32 years and current asthma diagnosis at either age.