Increased risk of second malignancies after in situ breast carcinoma in a population-based registry

I Soerjomataram; W J Louwman; M J C van der Sangen; R M H Roumen; J W W Coebergh

doi:10.1038/sj.bjc.6603231

Table 3

Standardised incidence ratio (SIR) and absolute excess risk (AER) for second breast cancer and second other cancers after BCIS (breast carcinoma in situ), according to follow-up time

		Second breast cancer				Other second cancers
Period of follow-up	PYR^a	Obs^b	Exp^c	SIR	AER	Obs^b	Exp^c	SIR	AER
1–4 years	3596	33	9.7	3.4^d	65	31	18.9	1.6^d	34
5–9 years	1815	22	5.0	4.4^d	94	12	10.1	1.2	11
≥10 years	1127	6	3.3	1.8	24	9	7.4	1.2	14

^aPYR: person-years.

^bObs: observed numbers of second primary cancers.

^cExp: expected numbers of second primary cancers.

^d95% confidence interval excludes 1.