Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue fever

Anna P. Durbin; Maria José Vargas; Kimberli Wanionek; Samantha N. Hammond; Aubree Gordon; Crisanta Rocha; Angel Balmaseda; Eva Harris

doi:10.1016/j.virol.2008.03.028

Figure 4

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Comparison of cell populations identified by cellular marker in DHF versus DF patients. Significance was determined by students t test and was determined for DHF and DF cases only. PBMCs from DHF patients contained significantly greater populations of CD86⁺, CD32⁺ CD14⁺, and CD11c⁺ cells than did those from patients diagnosed with DF. In addition, significantly more DEN antigen was detected in the PBMCs of DHF patients as compared to DF cases. Black bars: DHF cases; speckled bars: DF cases; striped bars: dengue-negative controls. Error bars represent the standard error of the mean.