Most mammalian mRNAs are conserved targets of microRNAs

Robin C. Friedman; Kyle Kai-How Farh; Christopher B. Burge; David P. Bartel

doi:10.1101/gr.082701.108

Figure 6.

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Correlation of P_CT with mRNA destabilization. (A) Destabilization of human messages with exactly one 7mer-m8 3′UTR site to a transfected miRNA (Grimson et al. 2007). Messages were grouped into six equal bins based on the site P_CT. (B) Destabilization of human messages with exactly one 7mer-m8 3′UTR site to a transfected miRNA (Grimson et al. 2007), considering only those sites that were not conserved in either mouse, rat, or dog.