Elastase- and LPS-exposed mice display altered responses to rhinovirus infection

Umadevi Sajjan; Shyamala Ganesan; Adam T. Comstock; Jee Shim; Qiong Wang; Deepti R. Nagarkar; Ying Zhao; Adam M. Goldsmith; Joanne Sonstein; Marisa J. Linn; Jeffrey L. Curtis; Marc B. Hershenson

doi:10.1152/ajplung.00150.2009

Fig. 1.

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Elastase/LPS treatment induced parenchymal and airway inflammation. Formalin-fixed, paraffin-embedded lungs harvested from PBS, elastase, LPS, or a combination of elastase/LPS-treated mice were stained with hematoxylin and eosin (H&E). PBS-treated mice (A and B) showed no obvious inflammation. Elastase-treated mice (C and D) showed mild inflammation with macrophages (arrowheads) being the predominant cell type. LPS-treated mice (E and F) showed mild inflammation with lymphocytes and neutrophils (arrowhead) being predominant cell types. Elastase/LPS-treated mice (G and H) showing moderate widespread inflammation with neutrophils (single arrowhead) and macrophages (double arrowheads). Arrows in C, E, and G show inflammatory foci. Images shown are typical of 4–6 independent experiments.