Elastase- and LPS-exposed mice display altered responses to rhinovirus infection

Umadevi Sajjan; Shyamala Ganesan; Adam T. Comstock; Jee Shim; Qiong Wang; Deepti R. Nagarkar; Ying Zhao; Adam M. Goldsmith; Joanne Sonstein; Marisa J. Linn; Jeffrey L. Curtis; Marc B. Hershenson

doi:10.1152/ajplung.00150.2009

Fig. 2.

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Elastase/LPS treatment induced goblet cell metaplasia. Paraffin lung sections of mice were stained with periodic acid-Schiff (PAS) reagent. PBS-treated mice did not show an increase in PAS-positive cells in either large or small airways (A and B). Elastase (C and D) or LPS-treated mice show few PAS-positive cells (arrows) in both large (C and E) and small airways (D and F). Elastase/LPS-treated mice show abundant PAS-positive cells (arrows) in large (G) and small airways (H), respectively. Images shown are typical of 4–6 independent experiments.