Chromatin remodeling: insights and intrigue from single-molecule studies

Bradley R Cairns

doi:10.1038/nsmb1333

Figure 1

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Modes of nucleosome remodeling. Remodelers enable access to nucleosomal DNA through sliding, ejection or H2A-H2B dimer removal. The SWR1 complex is unique in its ability to efficiently replace H2A-H2B dimers with dimers bearing a histone H2A variant (Htz1 or H2A.Z). Act denotes an activator with a binding site on the nucleosome.