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Nat Immunol. Author manuscript; available in PMC 2010 Mar 8.
Published in final edited form as:
Nat Immunol. 2008 Aug; 9(8): 847–856.
Published online 2008 Jul 11. doi: 10.1038/ni.1631
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Fig. 2

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Silica-mediated neutrophil influx in a model of acute lung inflammation is mediated by IL-1

(a) Silica crystals (200 µg / mouse) were orotracheally instilled into wild-type mice, MyD88/TRIF-double-deficient mice or IL-1R-deficient mice. 16–18h after instillation, neutrophil counts were monitored in the lung lavage by FACS. (b) In addition, wild-type mice, MyD88-/TRIF-double-deficient mice or IL-1R-deficient mice were orotracheally challenged with zymosan (50 µg / mouse) and processed as in (a).

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