ÐÏࡱá > þÿ · ¹ þÿÿÿ µ ¶ ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿì¥Á ð¿ bjbj|:|: Ì P P ÿÿ ÿÿ ÿÿ · Ã Ã Ã Ã Ã × × × × 8 \ k ì × G) W W W W W 2 2 2 ê( ì( ì( ì( ì( ì( ì( g* ¢ - d ì( à 2 2 2 2 6 ì(  à à W W Û )    : B à W à W ê(  2 ê(   à à  -àÊ × | F Â Þ ) 0 G)  m-  m-   à  2 2 2 ÿÿÿÿ ÿÿÿÿ ÿÿÿÿ ÿÿÿÿ ÿÿÿÿ ÿÿÿÿ ÿÿÿÿ : Q1 (n=13)Q2 (n=14)Q3 (n=17)Q4 (n=19)p for trenda<0.98 µmol/L0.98-1.136 µmol/L1.14-1.30 µmol/L>1.30 µmol/LAge (y)74.3±4.873.2±4.475.2±5.074.0±3.40.868Body height (cm)162.2±5.1164.3±5.5165.0±5.2164.4±6.30.303Body weight (kg)63.1±13.666.7±8.263.2±8.464.5±9.70.98WC (cm)86.6±13.789.6±7.685.5±8.686.9±10.00.748BMI (kg/m2)23.9±4.224.7±3.323.3±2.723.9±3.50.704TCHO (mmol/L)5.0±0.75.0±0.744.66±0.835.35±0.980.274LnTG (mmol/L)-0.19±0.360.33±0.500.37±0.410.33±0.590.01HDL-C (mmol/L)1.45±0.211.32±0.351.22±0.251.38±0.260.42LDL-C (mmol/L)3.03±0.582.94±0.522.80±0.703.27±0.780.342Sugar-AC (mmol/L)5.24±0.435.44±0.625.79±0.846.67±2.020.001Se (µmol/L)0.84±1.01.07±0.041.22±0.051.43±0.08< 0.0001Current smoking (%)15.435.711.815.80.565Current drinking (%)30.835.735.321.10.512HTN (%)61.542.952,947.40.598DM (%)014.341.215.80.158Lipid Tx (%)15.421.45.926.30.62Vegetarian (%)0000-Exercise (min/week)358.5±198.1386.4±140.2330.0±247.6317.9±243.20.786Vitamin-mineral supplement users (%)76.978.670.668.40.498Table S1. General characteristics by quartiles of serum selenium in men Table S2. General characteristics by quartiles of serum selenium in women Q1 (n=37)Q2 (n=37)Q3 (n=32)Q4 (n=31)p for trenda<0.98 µmol/L0.98-1.136 µmol/L1.14-1.30 µmol/L>1.30 µmol/LAge (y)71.0±5.168.9±3.069.7±3.471.6±4.70.495Body height (cm)152.5±6.0153.2±6.3152.0±4.6153.2±5.60.853Body weight (kg)55.4±8.855.1±8.454.7±7.251.2±6.30.039WC (cm)80.92±9.079.6±7.880.5±7.776.0±8.30.035BMI (kg/m2)23.8±3.523.4±2.923.7±2.521.8±2.60.016TCHO (mmol/L)5.09±0.885.39±0.915.78±0.915.96±0.97< 0.0001LnTG (mmol/L)0.21±0.410.15±0.490.25±0.480.30±0.460.325HDL-C (mmol/L)1.44±0.291.55±0.371.65±0.481.62±0.360.028LDL-C (mmol/L)3.0±0.743.16±0.673.41±0.613.59±0.65< 0.0001Sugar-AC (mmol/L)5.38±0.825.76±1.465.55±0.715.33±0.520.684Se (µmol/L)0.85±0.091.07±0.041.22±0.051.44±0.1< 0.0001Current smoking (%)00100.61Current drinking (%)3421 0.355HTN (%)43.245.946.941.90.953DM (%)10.810.89.43.20.283Lipid Tx (%) 24.316.228.122.6 0.84Vegetarian (%)5.42.709.70.574HRT2729.721.925.80.73Exercise (min/week)334.3±202353.1±248.2318.9±240.8342.3±240.30.95Vitamin-mineral supplement users (%)70.37381.393.5 0.016 Abbreviations: WC, waist circumference; TCHO, total cholesterol; LnTG, log transformation of triglycerides; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; Se, serum selenium; Sugar-AC, fasting serum glucose; HTN, hypertension; DM, diabetes mellitus; Lipid Tx, hyperlipidemia treatment; HRT, hormone replacement treatment. aP value for trend in percentages or means across quartiles of serum selenium Table S3. Linear regression models showing standardized coefficients with serum selenium concentrations as independent variable in men TCHOLnTGHDL-CLDL-CSugar-ACModelBetaP-valueBetaP-valueBetaP-valueBetaP-valueBetaP-valueModel 10.1710.1760.3250.006-0.0820.5120.1500.2360.4280.001Model 20.1570.2180.3200.008-0.0900.4700.1360.2880.4130.001Model 30.1710.1730.2890.021-0.0970.4640.1560.2130.377a0.002aAbbreviations: TCHO, total cholesterol; LnTG, log transformation of triglycerides; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; Se, serum selenium; Sugar-AC, fasting serum glucose Model 1: adjusted for age, sex, and BMI Model 2: adjusted for age, sex, BMI, current smoking, current drinking and vegetarianx diet, and physical activity Model 3: adjusted for age, sex, BMI, current smoking, current drinking and vegetarian diet, and physical activity, hormone replacement therapy, cholesterol-lowering medication, Vitamin supplement, diabetes mellitus, hypertension a Modified Model 3: Diabetes mellitus was excluded in Model 3 Table S4. Linear regression models showing standardized coefficients with serum selenium concentrations as independent variable in women TCHOLnTGHDL-CLDL-CSugar-ACModelBetaP-valueBetaP-valueBetaP-valueBetaP-valueBetaP-valueModel 10.313<0.0010.0960.2780.1500.0840.2920.0010.010.905Model 20.310<0.0010.0910.2980.1560.070.2870.0010.0030.973Model 30.299<0.0010.0630.4980.1830.0460.2690.004-0.085a0.932a Abbreviations: TCHO, total cholesterol; LnTG, log transformation of triglycerides; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; Se, serum selenium; Sugar-AC, fasting serum glucose Model 1: adjusted for age, sex, and BMI Model 2: adjusted for age, sex, BMI, current smoking, current drinking and vegetarianx diet, and physical activity Model 3: adjusted for age, sex, BMI, current smoking, current drinking and vegetarian diet, and physical activity, hormone replacement therapy, cholesterol-lowering medication, Vitamin supplement, diabetes mellitus, hypertension a Modified Model 3: Diabetes mellitus was excluded in Model 3 ) * 5 6 7 8 9 E F W X h i u v w x íÞÍÀÍÀÍÀÍÀ¬~o\o\o\o\oL~ÍÀÍÀ h;C hàC 6CJ aJ nH tH $h;C hàC CJ OJ QJ aJ nH tH h;C hàC CJ aJ nH tH h;C hàC CJ aJ nH tH h;C hàC CJ aJ 'h;C hàC CJ H*OJ QJ aJ nH tH 'h;C hàC 6CJ OJ QJ aJ nH tH h%o/ hàC aJ nH tH h%o/ hàC OJ QJ aJ nH tH h;C hÁ9L CJ aJ nH tH $h;C hÁ9L CJ OJ QJ aJ nH tH * 7 ê Ò Ò Ò Ò Ò $dà $üÿÜ &#$/µ If a$gdàC dà $üÿÜ &#$/µ If gdàC 7 8 9 F X T ? 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