Table 1
Characteristics of the study groups.
| Controls (n = 25) | AN pre-treatment (n = 16) | AN post-treatment (n = 16) | |
|---|---|---|---|
| Age (years) | 22.9 ± 0.50 | 24.9 ± 1.34 | 24.9 ± 1.34 |
| Body mass index (kg/m2) | 21.8 ± 0.38 | 15.7 ± 0.30* | 17.5 ± 0.23*+ |
| Body fat content (bodystat) (%) | 21.9 ± 1.21 | 9.3 ± 1.65* | 12.8 ± 1.38*+ |
| Body fat content (DEXA) (%) | 26.4 ± 1.79 | 13.9 ± 1.44* | 18.0 ± 1.38*+ |
| Lean body mass (kg) | 52.5 ± 2.03 | 38.9 ± 1.3* | 41.3 ± 0.96* |
| Resting energy expenditure (kcal/day) | 1400.1 ± 35.92 | 1060.0 ± 40.25* | 1176.3 ± 25.05*+ |
| Fasting glucose (mmol/l) | 4.4 ± 0.07 | 3.9 ± 0.09* | 4.2 ± 0.08+ |
| Total cholesterol (mmol/l) | 4.2 ± 0.14 | 4.6 ± 0.26 | 5.2 ± 0.27*+ |
| HDL-cholesterol (mmol/l) | 1.6 ± 0.08 | 1.5 ± 0.10 | 1.6 ± 0.08 |
| LDL-cholesterol (mmol/l) | 2.1 ± 0.09 | 2.4 ± 0.18 | 3.0 ± 0.21*+ |
| Free fatty acids (mmol/l) | 0.64 ± 0.06 | 0.16 ± 0.02* | Not measured |
| Total serum protein (g/l) | 79.1 ± 1.49 | 68.7 ± 2.01* | 75.5 ± 1.04+ |
| Albumin (g/l) | 46.4 ± 1.22 | 43.8 ± 1.12 | 47.6 ± 0.72+ |
| Total bone mineral density (g/cm2) | 1.09 ± 0.02 | 1.04 ± 0.02* | Not measured |
| Lumbar (L1-L4) bone mineral density (g/cm2) | 1.03 ± 0.03 | 0.86 ± 0.03* | Not measured |
| Proximal femur bone mineral density (g/cm2) | 0.98 ± 0.02 | 0.78 ± 0.04* | Not measured |
| IGF-1 (ng/ml) | NA | 156 ± 18 | NA |
| MIC-1 (pg/ml) | 1051 ± 83 | 1872 ± 200* | 1530 ± 169*+ |
| Leptin (ng/ml) | 11.8 ± 1.78 | 0.97 ± 0.23* | 2.6 ± 0.66*+ |
Anthropometric, hormonal and biochemical characteristics of the control group of normal-weight healthy women and patients with anorexia nervosa both before (AN pre-treatment) and after (AN post-treatment) treatment. Values are means ± SEM. Statistical significance is from unpaired t-test or Mann-Whitney test (AN vs. controls) and from paired t-test or Wilcoxon Signed Rank Test (post- vs. pre-treatment values in AN) as appropriate. *p < 0.05 vs. controls; +p < 0.05 vs. pre-treatment values. NA - not available