The Wnt/β-catenin pathway regulates growth and maintenance of colonospheres

Shailender S Kanwar; Yingjie Yu; Jyoti Nautiyal; Bhaumik B Patel; Adhip PN Majumdar

doi:10.1186/1476-4598-9-212

Figure 7

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Downregulation of β-catenin inhibits transcriptional activity of TCF/LEF in parental colon cancer cells and the corresponding spheroids/colonospheres. TCF/LEF transcription activity in HCT-116 wt parental and colonosphere-derived cells is downregulated in the corresponding β-catenin transfected cells. *p < 0.001, compared to the corresponding vector-treated controls