The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

Tullia Lindsten; Andrea J. Ross; Ayala King; Wei-Xing Zong; Jeffrey C. Rathmell; Helena A. Shiels; Eugen Ulrich; Katrina G. Waymire; Patryce Mahar; Kenneth Frauwirth; Yifeng Chen; Michael Wei; Vicki M. Eng; David M. Adelman; M. Celeste Simon; Averil Ma; Jeffrey A. Golden; Gerard Evan; Stanley J. Korsmeyer; Grant R. MacGregor; Craig B. Thompson

doi:10.1016/s1097-2765(00)00136-2

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Mol Cell. Author manuscript; available in PMC 2011 Mar 15.

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Mol Cell. 2000 Dec; 6(6): 1389–1399.

doi: 10.1016/s1097-2765(00)00136-2

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Table 1

Hematological Profile of bax^-/-bak^-/- and Control Mice

Genotype	WBC	Neutrophils	Lymphocytes	RBC
bax^-/-bak^-/-
1	15.3	4.1	10.0	7.4
2	24.2	2.5	20.4	4.6
3	28.7	2.0	26.0	9.5
4	39.2	5.1	31.9	8.8
bax^+/-bak^-/-
1	11.1	3.7	5.5	10.1
2	8.6	1.3	6.5	9.5
bax^+/+bak^-/-
1	3.7	1.2	2.4	9.8
2	4.6	0.7	3.6	9.8
bax^+/+bak^+/-
1	6.4	1.6	4.7	9.8
2	5.7	1.3	4.2	8.8
bax^+/+bak^+/+
1	4.7	0.7	3.8	9.9
2	4.8	0.5	4.0	9.3
3	4.3	1.3	2.9	10.3

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The number of white blood cells (WBC), neutrophils, lymphocytes (× 10³/μl), and red blood cells (RBC, × 10⁶/μl) was determined using a Hemavet 1500 apparatus.