FIGURE 7.

Parasitemia time course and tissue inflammation of mice infected with wild type trypomastigotes or TcCPX overexpressers. Behavior of wild type (WT) and TcCPX-overexpressing-trypomastigotes in experimental mice infections. Two month-old BALB/c mice were infected by intraperitoneal inoculation with 1 × 10⁶ metacyclic trypomastigote forms. Parasitemia and histopathology were analyzed as described under “Experimental Procedures.” A, parasitemia (trypomastigotes/50 fields) levels elicited by the wild type and TcCPX overexpresser strains. Values are given as means ± S.E. B, microphotographs of skeletal muscle tissue sections from mice inoculated with wild type (left) and TcCPX overexpressers (right) (magnification, ×400). Arrows in the right panel (TcCPX) indicate inflammatory infiltrates.