PGC-1 coactivators in the control of energy metabolism

Chang Liu; Jiandie D. Lin

doi:10.1093/abbs/gmr007

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Acta Biochim Biophys Sin (Shanghai). 2011 Apr; 43(4): 248–257.

Published online 2011 Feb 16. doi: 10.1093/abbs/gmr007

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The working model of PGC-1 coactivators PGC-1α and PGC-1β regulate diverse metabolic programs through coactivating selective transcriptional factors (TF) associated with regulatory elements of target genes. PGC-1 recruits HAT, SWI/SNF chromatin-remodeling, Sirt1 deacetylase, and mediator complexes to modulate the epigenetic status of chromatin.