PMC full text:
Clin Cancer Res. Author manuscript; available in PMC 2012 Apr 1.
Published in final edited form as:
Clin Cancer Res. 2011 Apr 1; 17(7): 1867–1874.
Published online 2011 Feb 15. doi: 10.1158/1078-0432.CCR-10-2021Table 3
Multivariate analysis of the survival outcomes by androgen receptor status
| Models | N | Hazard Ratio (95% CI*) | ||
|---|---|---|---|---|
| Cases | Endpoints | AR-negative | AR-positive | |
| Breast cancer specific survival | ||||
| All cases: | ||||
| Model1 | 1467 | 275 | 1.00 | 0.78 (0.60–1.03) |
| Model2 | 1467 | 275 | 1.00 | 0.96 (0.69–1.34) |
| ER-positive cases: | ||||
| Model1 | 1164 | 205 | 1.00 | 0.59 (0.41–0.85) |
| Model3 | 1164 | 205 | 1.00 | 0.68 (0.47–0.99) |
| ER-negative cases: | ||||
| Model1 | 303 | 70 | 1.00 | 1.46 (0.91–2.33) |
| Model3 | 303 | 70 | 1.00 | 1.59 (0.94–2.68) |
| Recurrence-free interval | ||||
| All cases: | ||||
| Model1 | 1467 | 288 | 1.00 | 0.80 (0.62–1.05) |
| Model2 | 1467 | 288 | 1.00 | 0.99 (0.72–1.36) |
| ER-positive cases: | ||||
| Model1 | 1164 | 217 | 1.00 | 0.62 (0.44–0.89) |
| Model3 | 1164 | 217 | 1.00 | 0.72 (0.50–1.05) |
| ER-negative cases: | ||||
| Model1 | 303 | 71 | 1.00 | 1.39 (0.87–2.22) |
| Model3 | 303 | 71 | 1.00 | 1.54 (0.92–2.58) |
| Overall survival | ||||
| All cases: | ||||
| Model1 | 1467 | 576 | 1.00 | 0.90 (0.74–1.10) |
| Model2 | 1467 | 576 | 1.00 | 0.89 (0.71–1.13) |
| ER-positive cases: | ||||
| Model1 | 1164 | 460 | 1.00 | 0.68 (0.52–0.88) |
| Model3 | 1164 | 460 | 1.00 | 0.70 (0.53–0.91) |
| ER-negative cases: | ||||
| Model1 | 303 | 116 | 1.00 | 1.48 (1.02–2.13) |
| Model3 | 303 | 116 | 1.00 | 1.42 (0.95–2.13) |
*CI denotes confidence interval.
Model1: Adjust for age at diagnosis (years).
Model2: Adjust for age at diagnosis (years), estrogen receptor status (positive, negative), date of diagnosis (months), disease stage (I, II, III), grade (I, II, III), radiation treatment (yes, no, missing), chemotherapy and hormonal treatment (no/no, yes/no, no/yes, yes/yes, missing).
Model3: Adjust for age at diagnosis (years), date of diagnosis (months), disease stage (I, II, III), grade (I, II, III), radiation treatment (yes, no, missing), chemotherapy and hormonal treatment (no/no, yes/no, no/yes, yes/yes, missing).