Increased Risk of Severe Infant Anemia Following Exposure to Maternal HAART, Botswana

Scott Dryden-Peterson; Roger L. Shapiro; Michael D. Hughes; Kathleen Powis; Anthony Ogwu; Claire Moffat; Sikhulile Moyo; Joseph Makhema; Max Essex; Shahin Lockman

doi:10.1097/QAI.0b013e31820bd2b6

Table 2

Cumulative incidence of severe anemia

	Cumulative Incidence of Grade 3 or 4 Anemia^a			Between Group Comparisons

	HAART-BF	ZDV-BF	ZDV-FF	HAART-BF vs. (ZDV-BF and ZDV-FF)

	no. (%)	no. (%)	no. (%)	Odds Ratio (95% CI)	p-value^b
Birth	7/650 (1.1)	1/466 (0.2)	0/475 (0)	OR: 10.2 (1.26, 83.4)	0.007

				HAART-BF vs. ZDV-BF		HAART-BF vs. ZDV-FF

				Odds Ratio (95% CI)	p-value^b	Odds Ratio (95% CI)	p-value^b

1 month	18/677 (2.7)	6/489 (1.2)	7/495 (1.4)	OR: 2.20 (0.87, 5.58)	0.089	OR: 1.90 (0.79, 4.59)	0.145

3 months^c	58/674 (8.6)	17/484 (3.5)	8/486 (1.7)	OR: 2.59 (1.49, 4.50)	<0.001	OR: 5.63 (2.66, 11.9)	<0.001

6 months^c	82/655 (12.5)	25/468 (5.3)	11/469 (2.5)	OR: 2.53 (1.59, 4.04)	<0.001	OR: 5.96 (3.14, 11.3)	<0.001

Note. Infants with incident anemia and infants with hemoglobin measurement at scheduled time points are included in the denominator for incidence calculation. Only scheduled hemoglobin measurements within 5 days of birth and 1 month of age, and within 10 days of later time points are included. Hb, hemoglobin; OR, odds ratio.