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Published online 2011 Jun 1. doi: 10.1172/JCI45685
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Figure 6

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HIV-specific responses by tissue-like memory B cells following siRNA-mediated downregulation of the inhibitory receptor FCRL4.

Tissue-like memory B cells of 7 HIV-infected individuals were either untreated or treated with control or FCRL4-specific siRNA and stimulated in the presence of CD19-depleted autologous PBMCs with F(ab′)2 anti-IgA/G/M, CpG, and IL-21 for 4 days prior to measurement of B cell response by ELISPOT assay. Each individual is represented by a color-coded symbol. Horizontal bars indicate medians.

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