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Figure 8

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Factors affecting proliferation of tissue-like memory B cells following siRNA-mediated downregulation of FCRL4.

siRNA-treated tissue-like memory B cells of (A) 15 HIV-infected individuals stimulated for 4 days with F(ab′)2 anti-IgM or anti-IgG and CpG; (B) 6 HIV-infected individuals stimulated with F(ab′)2 anti-IgA/G/M and either CD40L or CpG; and (C) 7 HIV-infected individuals stimulated with anti-IgM containing an Fc portion (Fc+) or not (Fc) and CpG. The stimulation indices were calculated as described in Figure Figure5.5.

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