Figure 1
The CREBBP gene is mutated in DLBCL
a, Schematic diagram of the CREBBP gene (top) and protein (bottom). Exons are color coded according to the corresponding protein functional domains (CH, cysteine-histidine rich; KIX, CREB-binding; Bromo, bromodomain; HAT, histone acetyltransferase; Q, poly glutamine stretch). Color-coded symbols depict distinct types of mutations. b, Sequencing traces of representative mutated DLBCL tumor samples and paired normal DNA; arrows point to the position of the nucleotide change (amino acid change shown at the bottom). c, Distribution of CREBBP mutations in major DLBCL subtypes; on top, actual number of mutated samples over total analyzed.