Figure 1

a, Schematic diagram of the CREBBP gene (top) and protein (bottom). Exons are color coded according to the corresponding protein functional domains (CH, cysteine-histidine rich; KIX, CREB-binding; Bromo, bromodomain; HAT, histone acetyltransferase; Q, poly glutamine stretch). Color-coded symbols depict distinct types of mutations. b, Sequencing traces of representative mutated DLBCL tumor samples and paired normal DNA; arrows point to the position of the nucleotide change (amino acid change shown at the bottom). c, Distribution of CREBBP mutations in major DLBCL subtypes; on top, actual number of mutated samples over total analyzed.