Table 2
Descriptors of Muscarinic Receptor
Agonism in Guinea Pig Ileum for Carbachol and Oxotremorinea
| agonist | τ | pKa | log(τ/KA) | Δlog(τ/KA) |
|---|---|---|---|---|
| Control | ||||
| carbarchol | 1500 | 4.04 | 7.22 | 0.42 |
| oxotremorine | 120 | 5.56 | 7.64 | |
| After Alkylation | ||||
| carbarchol | 11 | 4.09 | 5.14 | 0.41 |
| oxotremorine | 0.71 | 5.69 | 5.55 | |
aEm,
the maximal response of the tissue, was obtained by measuring the
contraction of complete depolarization of guinea pig ileal strips
to KCl.