Table 1
Several gene targets of hypoxia inducible factors described in liver are listed, along with the broad category or categories of physiologic or pathologic activity to which major functions of the gene are attributed. Further information appears in the accompanying text.
| Gene | Function | Reference |
|---|---|---|
| Plasminogen activator Inihibitor-1 (PAI-1) | Inflammation, thrombosis, metastasis | Kietzmann (1999), Anh (2010) |
| Prolyl-4 hydroxylase alpha-2 | Fibrosis, collagen stabilization | Copple (2011) |
| Heme Oxygenase 1 (HO1) | Oxidative stress, inflammation | Yeligar (2011) |
| Vascular endothelial growth factor | Angiogenesis, tumor vascularization, ischemia-reperfusion | Corpechot (2002), Maeno (2005), Nakamura (2005), Redaelli (2005) |
| Erythropoietin | Erythrocyte proliferation, liver regeneration | Rankin (2007) |
| Ceruloplasmin | Copper metabolism | Martin (2005) |
| Glukokinase | Metabolism | Roth (2004) |
| Bone Morphogenetic Protein | Tumorigenesis | Maegdefrau (2009) |