Microbiological Characterization in Children with Aggressive Periodontitis

L.M. Shaddox; H. Huang; T. Lin; W. Hou; P.L. Harrison; I. Aukhil; C.B. Walker; V. Klepac-Ceraj; B.J. Paster

doi:10.1177/0022034512456039

Table 2.

Significant Levels of Species Abundance in the Different Sites/Groups

Most Abundant Species in LAP Disease Sites (DD)	DD	DH	HC	HS	p Value
Aggregatibacter actinomycetemcomitans_ot531_AA84	1.8235^a	0.2143^b	0.4444^b	1.2308^ab	<.0001
Aggregatibacter actinomycetemcomitans_ot531_P02	2.1765^a	0.4286^b	0.4444^b	1.5385^ab	0.0002
Most Abundant Species in LAP Healthy Sites (DH)	DD	DH	HC	HS	p Value
Capnocytophaga sp clones BM058 and BU084_ot329_O08	0.0588^a	0.4286^b	0.2222^ab	0.3077^ab	0.0364
Capnocytophaga sputigena_ot775_AC15	0.0000^a	0.1786^b	0.0000^ab	0.0000^ab	0.0308
Catonella morbi and sp clone BR063_ot164_165_O56	0.7941^a	1.3214^b	0.6667^ab	1.0000^ab	0.0441
Eubacterium sp clone 7 69_ot846_AB31	0.0000^a	0.1786^b	0.0000^ab	0.0000ab	0.0028
Eubacterium[11][G-7] yurii_ot377_W84	1.3235^a	2.1071^b	1.2222^ab	1.4615^ab	0.0344
Fusobacterium periodontium_ot201_R20	0.2941^a	1.0714^b	0.5556^ab	0.6154^ab	0.0086
Kingella denitrificans_ot582_X41	0.0294^a	0.2500^b	0.0000^ab	0.0000^ab	0.0436
Prevotella melaninogenica and sp clone BE073_ot298_469_T81	0.0588^a	0.4286^b	0.0000^ab	0.0000^ab	0.0142
Selenomonas sp clones DS071 and EW084_ot138_146_Q52	0.2647^a	0.7857^b	0.1111^ab	0.7692^ab	0.0214
Selenomonas sp clones DS071 and EW084_ot138_146_X69	0.1176^a	0.5357^b	0.0000^ab	0.4615^ab	0.0088
Streptococcus anginosus and intermedius_ot543_644_AB82	0.5294^a	1.3214^b	1.2222^ab	0.5385^ab	0.0048
Streptococcus anginosus and intermedius_ot543_644_Q62	1.7647^a	2.8929^b	2.6667^ab	2.2308^ab	0.0021
Streptococcus constellatus and intermedius_ot576_644_F48	0.9412^a	1.8214^b	1.7778^ab	1.1539^ab	0.0056
Streptococcus mitis bv2 and sp clone FP064_ot069_398_Q64	0.1471^a	0.5357^b	0.4444^ab	0.2308^ab	0.0146
Streptococcus sanguinis and sp clone C3MLM097_ot058_758_AB75	0.0882^a	0.7143^b	0.5556^ab	0.5385^ab	0.0026
Streptococcus sanguinis and sp clone C3MLM097_ot058_758_AB78	0.1176^a	1.0714^b	0.6667^ab	0.6154^ab	0.0002
Veillonella atypica and parvula_ot161_524_Q67	1.0000^a	2.0714^b	2.0000^ab	1.5385^ab	0.0066
Veillonella EF509966 Crohns_not_oral_AD63-C	0.8529^a	1.6786^b	1.5556^ab	1.2308^ab	0.0074
Veillonella parvula_ot161_D96	0.0294^a	0.2143^b	0.1111^ab	0.0769^ab	0.0386
Veillonella parvula_ot161_M04	0.3529^a	0.8571^b	0.6667^ab	0.5384^ab	0.0169
Most Abundant Species in Healthy Control Sites (HC)	DD	DH	HC	HS	p Value
Bergeyella sp clone AK152_ot322_AD84	0.1176^a	0.1200^ab	0.6600^b	0.1500^ab	0.0210
Campylobacter concisus_ot575_X33	0.0000^a	0.0000^a	0.1111^b	0.0000^b	0.0062
Haemophilus parainfluenzae_ot718_W79	0.7941^a	1.1429^a	1.8889^b	1.7692^b	0.0412
Neisseria flavescens_ot610_AA76	0.1176^a	0.2500^ab	0.5556^b	0.0769^ab	0.0357
Rothia dentocariosa and mucilaginosa_ot587_681_E52	0.0000^a	0.1786^ab	0.3333^b	0.0769^ab	0.0304
Streptococcus Cluster II_ot071_755_758_Q59	0.7353^a	1.7500^a	2.3333^b	1.4616^b	0.0007
Streptococcus Cluster III_ot755_758_767_768_Q65	0.9706^a	1.7857^b	2.0000^b	1.2308^ab	0.0085
Streptococcus constellatus and intermedius_ot576_644_AB77	0.7353^a	1.7857^b	2.0000^b	0.8462^ab	0.0019
Streptococcus parasanguis I and II_ot411_721_AB05	0.1176^a	0.4286^b	0.6667^b	0.2308^ab	0.0101
Treponema lecithinolyticum_ot653_D52	0.0000^a	0.0000^a	0.1111^b	0.0769^b	0.0524
Most Abundant Species in Healthy Sibling Sites (HS)	DD	DH	HC	HS	p Value
Actinomyces Cluster II_ot180_181_671_701_AC99	0.0000^a	0.0000^ab	0.0000^ab	0.0769^b	0.0310
Actinomyces meyeri and odontolyticus_ot671_701_AA88	0.0000^a	0.0000^ab	0.0000^ab	0.0769^b	0.0310
Actinomyces sp strain B27SC_ot178_W02	0.0000^a	0.0000^ab	0.0000^ab	0.0769^b	0.0310
Cardiobacterium valvulum_ot540_AD79	0.0000^a	0.0714^a	0.0000^b	0.4615^b	0.0003
Cardiobacterium valvulum_ot540_AD80	0.0000^a	0.0357^a	0.0000^b	0.2308^b	0.0008
Leptotrichia hofstadii_ot224_AA58	0.0000^a	0.0000^ab	0.0000^ab	0.1539^b	0.0310
Porphyromonas endodontalis_ot273_N99	0.000^a	0.0000^ab	0.0000^ab	0.0769^b	0.0310
Sphaerocytophaga S3_ot337_X23	0.0882^a	0.2857^ab	0.4444^ab	0.5385^b	0.0370
SR1[G-1] sp _X112_ot345_AC72	0.0000^a	0.0000^ab	0.0000^ab	0.0769^b	0.0310
SR1[G-1] sp _X112_ot345_AC73	0.0000^a	0.0000^ab	0.0000^ab	0.0769^b	0.0310
Treponema denticola_ot584_O40	0.0000^a	0.0000^ab	0.0000^ab	0.0769^b	0.0310
Treponema sp clone _T021_ot231_AC45	0.0000^a	0.0000^ab	0.0000^ab	0.0769^b	0.0310

Abundance values are represented here as the least-square mean intensity value (from HOMIM ranked signal scale 0-5) for each group. Means followed by different superscript letters represent statistical differences among groups by ANOVA. DD = diseased sites in children with disease; DH = healthy sites in children with disease; HS = healthy site in healthy sibling; HC = healthy site in healthy control child. Different letters show statistically significant differences among groups.